| Abstract Detail
Phytochemistry: From atoms to organisms Porras, Gina [1], Chassagne, Francois [1], Lyles, James [1], Marquez, Lewis [1], Dettweiler, Micah [1], Salam, Akram [1], Samarakoon, Tharanga [1], Shabih, Sarah [1], Raschid Farrokhi, Darya [1], Quave, Cassandra [1]. Plant Natural Products and the Future of Antimicrobial Drug Discovery. Antimicrobial resistance represents a serious threat to human health across the globe. The cost of bringing a new antibiotic from discovery to market is high and return on investment is low. Furthermore, the development of new antibiotics has slowed dramatically since the 1950s' golden age of discovery. Plants produce a variety of bioactive secondary metabolites that could be used to fuel the future discovery pipeline. I present the findings of the first major review of the antimicrobial literature on the bioactivity of plant extracts. We identified a total of 6,083 articles published between 1946 and 2019 and then reviewed 66% of these (4,024) focusing on articles published between 2012 and 2019. A rigorous selection process was implemented using clear inclusion and exclusion criteria, yielding data on 958 plant species derived from 483 scientific articles. Antibacterial activity is found in 51 of 79 vascular plant orders throughout the phylogenetic tree. I highlight the most promising species recommended for further antimicrobial investigation.
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1 - Emory University, Dermatology, 615 Michael St., Whitehead 105L, Atlanta, GA, 30322, USA
Keywords:
antimicrobial
Ethnobotany
natural products
antibiotics.
Presentation Type: Colloquium Presentations
Session: C05, Phytochemistry: From Atoms to Organisms
Location: /
Date: Wednesday, July 21st, 2021
Time: 1:15 PM(EDT)
Number: C05012
Abstract ID:601
Candidate for Awards:None |
