Abstract Detail

Phytochemistry: From atoms to organisms

Van Buiten, Charlene [1], Raskin, Ilya [2], Elias, Ryan [3], Wu, Guojun [4], Lam, Yan Y. [4], Yennawar, Neela [5], Pacheco, Carlos [6], Hatzakis, Emmanuel [7], Lambert, Joshua [8], Zhao, Liping [9].

Beyond Bioavailability: Polyphenols Offer Pre-Absorptive Benefits for Improving Intestinal and Metabolic Health via Intraluminal Activities.

The use of natural products to treat illness or broadly improve human health dates back thousands of years ago through herbal remedies or regular consumption of certain foods. Technological advances have parlayed these traditional applications into pharmaceutical and nutraceutical product development, where the efficacy of treatments has been targeted by attempts to increase bioavailability, or the rate and extent of absorption of a given bioactive compound. Polyphenols are bioactive compounds found in plant-based food products and have been noted for a variety of health benefits including anti-oxidant, anti-inflammatory and anti-obesity effects. Despite these benefits, their poor bioavailability has been viewed as a limiting factor in their usefulness as nutraceutical treatments. Recent studies demonstrate multiple mechanisms by which unabsorbed polyphenols can protect against chronic inflammatory diseases. Within the context of celiac disease, the anti-nutritional characteristics of polyphenols allow for protection against immunostimulatory gluten peptides, reducing inflammation and intestinal permeability. Poorly absorbed polyphenols have also been shown to modify the gut microbiome and reverse metabolic syndrome. These effects may potentially be attributed to the intraluminal radical scavenging abilities of polyphenols, which modifies the redox environment of the gastrointestinal tract. These findings suggest that polyphenols confer benefits to the consumer because of their poor bioavailability rather than in spite of it, and that these pre-absorptive mechanisms should be explored in a wider range of chronic inflammatory diseases.

1 - Colorado State University, Food Science and Human Nutrition, 502 West Lake Street, Fort Collins, CO, 80524
2 - Rutgers University, Plant Biology, 59 Dudley Rd, New Brunswick, NJ, 08901, United States
3 - Pennsylvania State University, Food Science, 336 Rodney Erickson Food Science Building, University Park, PA, 16802, USA
4 - Rutgers University, Biochemistry and Microbiology, New Brunswick, NJ, 08901, United States
5 - Pennsylvania State University, Huck Institute of Life Sciences, 0088 Althouse Lab, University Park, PA, 16802, United States
6 - New Jersey Institute of Technology, Chemistry and Environmental Science, B006 Tiernan Hall, Newark, NJ, 07102, USA
7 - Ohio State University, Food Science and Technology, 233 Parker Food Science and Technology Building, Columbus, OH, 43210, USA
8 - Pennsylvania State University, Food Science, 332 Rodney Erickson Food Science Building, University Park, PA, 16802, United States
9 - Colorado State University, Food Science and Human Nutrition, 502 West Lake Street, Fort Collins, CO, 80524, United States

Keywords:
polyphenols
bioavailability
redox environment
celiac disease
metabolic syndrome
inflammation.

Presentation Type: Colloquium Presentations
Session: C05, Phytochemistry: From Atoms to Organisms
Location: /
Date: Wednesday, July 21st, 2021
Time: 1:00 PM(EDT)
Number: C05011
Abstract ID:66
Candidate for Awards:None