Abstract Detail

Gene regulatory networks in fungal development and morphogenesis - towards fungal evo-devo

Nagy, Laszlo G. [1].

Towards understanding conserved gene regulatory networks in fungi: an update on the FUNCODE Project.

Fungal genomics is fueling a wide range of basic and applied research. Since the first fungal genome projects, genome sequencing (e.g. via the 1000 Fungal Genomes Project) has come a long way and has overall been a great success story. To grasp fungal biology in its full complexity, however, it is crucial to move our understanding of fungal genomes beyond primary coding sequence. The functioning of eukaryotic cells is to a large extent determined by transcriptional activity, including gene expression patterns, splicing variants, non-coding RNA species, among others, which, in turn is determined by the structure and hierarchy of gene regulatory networks. The FUNCODE (Fungal Comparative ENCODE) project aims to systematically reconstruct gene regulatory circuits on a genome-scale in 5 model fungi relevant to lignocellulose degradation and multicellular development. In this talk I summarize the objectives and structure of the project as well as progress made in the first two years. Emphasis is placed on the identification of sequence-specific DNA binding transcription factors, the evolution of transcription factor repertoires in fungi as well as their conservation across the fungal tree of life.

1 - Biological Research Center, Institute of Biochemistry, Temesvari krt 62, Szeged, Csongrad, 6726, Hungary

Keywords:
transcription factor
fungi
gene regulatory network.

Presentation Type: Symposium Presentation
Session: SY1, Gene regulatory networks in fungal development and morphogenesis - towards fungal evo-devo
Location: /
Date: Monday, July 19th, 2021
Time: 1:30 PM(EDT)
Number: SY1008
Abstract ID:270
Candidate for Awards:None